Science teaching, science learning

sharing evidence-based practices for undergraduate science faculty 

isoketals/isolevuglandins

Davies SS, Amarnath V, Brame CJ, Boutaud O, and Roberts LJ, II. Measurement of chronic oxidative and inflammatory stress by quantification of isoketal/levuglandin g-ketoaldehyde protein adducts using liquid chromatography tandem mass spectrometry. Nature Protocols 2: 2079-2091, 2007. 

Brame CJ, Boutaud O, Davies S, Yang T, Oates JA, Salomon RG, Roden DM, Morrow JD, and Roberts LJ, II. Modification of proteins by isoketal-containing oxidized phospholipids. J. Biol. Chem. 279: 13447-51, 2004.

Davies SS, Brame CJ, Boutaud O, and Roberts LJ, II. Measurement of isoketal protein adducts by liquid chromatography electrospray tandem mass spectrometry. Chapter in: Methods in Biological Oxidative Stress. K. Hensley and RA Floyd, eds., pp 127-136, 2003.

Boutaud O, Li J, Chaurand P, Brame CJ, Marnett LJ, Roberts LJ, II, and Oates JA. Oxygenation of arachidonic acid by cyclooxygenases generates reactive intermediates that form adducts with proteins. Adv Exp Med Biol. 500:133-137, 2001.

Strahl BD, Briggs SD, Brame CJ, Caldwell JA, Koh SS, Ma H, Cook RG, Shabanowitz J, Hunt DF, Stallcup MR, and Allis CD. Methylation of histone H4 at arginine 3 occurs in vivo and is mediated by the nuclear receptor coactivator PRMT1. Curr. Biol. 11: 996-1000, 2001.

Boutaud O, Brame CJ, Chaurand P, Li J, Rowlinson SW, Crews BC, Ji C Marnett LJ, Caprioli RM, Roberts LJ, II, and Oates JA. Characterization of the lysyl adducts of prostaglandin H-synthases that are derived from oxygenation of arachidonic acid. Biochemistry 40: 6948-6955, 2001.

Roberts LJ, II, Chen Y, Boutaud O, Davies SS, Morrow JD, Oates JA, and Brame CJ. Reactive products of the isoprostane pathway: isoketals and cyclopentenone A2/J2-isoprostanes. Chapter in: Advances in Prostaglanding and Leukotriene Research: Basic Science and New Clinical Applications. B. Samuelsson, R. Paoletti, GC Folco, E. Granstrom, and S. Nicosia, eds. Kluwer Academic Publishers, 2001.

Reich EE, Zackert WE, Brame CJ, Chen Y, Roberts LJ, II, Hachey DL, Montine TJ, and Morrow JD. Formation of novel D-ring and E-ring isoprostane-like compounds (D-4/E-4-neuroprostanes) in vivo from docosahexaenoic acid. Biochemistry 29: 2376-2383, 2000.

Roberts LJ, II, Brame CJ, Chen Y, and Morrow JD. Formation of novel reactive products via the isoprostane pathway. In: Proc. 5th Internat. Conf. On Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Other Related Diseases. KV Honn, S Nigam, L Marnett, and E Dennis, eds., Plenum Publishers, 2000.

Salomon RG, Sha W, Brame CJ, Kaur K, Subbanagounder G, O’Neil J, Hoff HF, and Roberts LJ, II. Protein adducts of iso[4]levuglandin E2 in oxidized low density lipoprotein. J. Biol. Chem. 274: 20271-20280, 1999.

Brame CJ, Boutaud O, Oates JA, and Roberts LJ, II. Characterization of lysyl adducts formed by the -ketoaldehyde prostanoids LGE2/D2. Biochemistry 38: 9389-9396, 1999.

Roberts LJ, II, Salomon RG, Morrow JD, and Brame CJ. New developments in the isoprostane pathway: identification of novel highly reactive gamma-ketoaldehydes (isolevuglandins) and characterization of their protein adducts. FASEB J. 13: 1157-1168, 1999.

Roberts LJ, II, Brame CJ, Chen Y, Morrow JD, and Salomon RG. Formation of reactive products of the isoprostane pathway: isolevuglandins and cyclopenteneone isoprostanes. Adv. Exp. Med. & Biol. 469: 335-341, 1999.

Brame CJ, Salomon RG, Morrow JD, and Roberts LJ, II. Identification of extremely reactive -ketoaldehydes as products of the isoprostane pathway. J. Biol. Chem. 274: 13139-13146, 1999.

Roberts LJ, II, Brame CJ, Chen Y, and Morrow JD. Novel eicosanoids: Isoprostanes and related compounds. Methods Mol. Biol. 120: 257-285, 1999.

Morrow JD, Chen Y, Brame CJ, Yang J, Sanchez SC, Xu J, Zackert WE, Awad JA, and Roberts LJ, II. The isoprostanes: unique prostaglandin-like products of free radical-catalyzed lipid peroxidation. Drug Metab. Rev. 31, 117-139, 1999.

Subbanagounder G, Salomon RG, Murthi KK, Brame CJ, and Roberts LJ, II. Total synthesis of iso[4]-levuglandin E2. J. Org. Chem. 62: 7658-7666, 1997.